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The use of Smartphone has become universal with little attention paid on health applications by phone users. Health applications on Smartphones are downloaded from various stores to inculcate positive health attitudes for an individual’s wellbeing. The study investigated the determinants of Smartphone health applications utilization among University of Lagos students, Nigeria. The study was guided by four null hypotheses. The study adopted a descriptive survey research design. The population of the study included all undergraduate students in University of Lagos. The sample of the study constituted of three hundred (300) respondents while simple random sampling and purposive sampling techniques were used. The instrument used for data collection was a validated questionnaire with reliability of r= 0.92. Chi-square statistical analysis was used for data analysis. The finding of the study revealed that technical knowledge, awareness, student field of study and attitude of students have significant influence on the utilization of Smartphone health application. Local mobile app developers should increase their marketing and advertising strategies for students to increase students’ awareness, mobile apps should be designed in such a way that the field of study should be taken into consideration and hardware manufacturers should produce devices that have long battery life span to encourage positive attitude of the students towards the use of mobile health applications
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